Neurology

AI-DBS study: protocol for a longitudinal prospective observational cohort study of patients with Parkinson’s disease for the development of neuronal fingerprints using artificial intelligence
Mariëlle J Stam, Martijn G J de Neeling, Bart J Keulen, Deborah Hubers, Rob M A de Bie, Rick Schuurman, Arthur W G Buijink, Bernadette C M van Wijk, Martijn Beudel

BMJ Open May 2025, 15 (5) e091563; DOI: 10.1136/bmjopen-2024-091563
Blood pressure variability and mortality in patients admitted with acute stroke in a tertiary care stroke centre (2016–2019): a retrospective cohort study
Mohamed Tawengi, Rizeq F Hourani, Tamader Alyaarabi, Ahmed Adel Elsabagh, Yazan Al-Dali, Rama Ghassan Hommos, Jawaher Baraka, Abdelaziz M Tawengi, Bushra M Abdallah, Ahmad Hatem, Sundus Sardar, Yahia Z Imam, Naveed Akhtar, Muhammad Zahid, Suhail Doi, Mohammed Ibn-Masud Danjuma, Abdelnaser Elzouki

BMJ Open May 2025, 15 (5) e095773; DOI: 10.1136/bmjopen-2024-095773
Non-invasive device to alleviate symptoms in people living with Parkinson’s: study protocol for a multicentre phase II double-blind randomised controlled trial
Viktoria Azoidou, Essa Bhadra, Kira Rowsell, Ellen Camboe, Kamalesh Dey, Alexandra Zirra, Corrine Quah, Caroline Budu, Thomas Boyle, David Gallagher, Alastair Noyce, Cristina Simonet

BMJ Open Apr 2025, 15 (4) e096051; DOI: 10.1136/bmjopen-2024-096051
Evaluating the occupation-based complex intervention for living well with anxiety and Parkinson’s disease (OBtAIN-PD) in community rehabilitation teams in the UK: a feasibility cluster randomised controlled trial protocol
Chris Lovegrove, Katrina Bannigan, Christopher Hayward, Wendy Ingram, Matthew Peter Bailey, Paigan Aspinall, Joanne Hosking, Ingrid Sturkenboom, Jonathan Marsden

BMJ Open Apr 2025, 15 (4) e079803; DOI: 10.1136/bmjopen-2023-079803
TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada
Roger Zemek, Lisa M Albrecht, Sharon Johnston, John Leddy, Andrée-Anne Ledoux, Nick Reed, Noah Silverberg, Keith Yeates, Monica Lamoureux, Charlotte Anderson, Nicholas Barrowman, Miriam H Beauchamp, Kitty Chen, Araba Chintoh, Achelle Cortel-LeBlanc, Miguel Cortel-LeBlanc, Daniel J Corwin, Stephanie Cowle, Kristine Dalton, Jennifer Dawson, Andrew Dodd, Khaled El Emam, Carolyn Emery, Erin Fox, Pamela Fuselli, Isabelle J Gagnon, Christopher Giza, Steven Hicks, David R Howell, Stephen Alexander Kutcher, Carlos Lalonde, Rebekah C Mannix, Christina L Master, Andrew R Mayer, Martin H Osmond, Rebecca Robillard, Kathryn J Schneider, Peter Tanuseputro, Ivan Terekhov, Richard Webster, Cheryl Lea Wellington

BMJ Open Apr 2025, 15 (4) e095292; DOI: 10.1136/bmjopen-2024-095292
STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection
Carlos Delfino, Cheryl Carcel, Xiaolei Lin, Paula Muñoz-Venturelli, Sharon L Naismith, Mark Woodward, Ruth Peters, Nirupama Wijesuriya, Meng Law, Ian H Harding, Xia Wang, Julian Elliott, Karin Leder, Owen Hutchings, Ximena Stecher, Sophia Zoungas, Craig S Anderson

BMJ Open Apr 2025, 15 (4) e089382; DOI: 10.1136/bmjopen-2024-089382
Efficacy of deep brain stimulation in treating monogenic dystonia symptoms: protocol for a systematic review
Beatriz Carmona-Hidalgo, Javier Quintero, Rocío Rodríguez-López, Juan Antonio Blasco-Amaro, Sylvia Boesch, Carola Reinhard

BMJ Open Apr 2025, 15 (4) e083127; DOI: 10.1136/bmjopen-2023-083127
Prognostic factors of disability progression in multiple sclerosis in real life: the OFSEP-high definition (OFSEP-HD) prospective cohort in France
Guillemin Francis, Casey Romain, Epstein Jonathan, Foucher Yohann, Laplaud David, Achit Hamza, Rollot Fabien, Leray Emmanuelle, Vukusic Sandra

BMJ Open Apr 2025, 15 (4) e094688; DOI: 10.1136/bmjopen-2024-094688
Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial
Daniel Thom, Richard Shek-kwan Chang, Natasha A Lannin, Zanfina Ademi, Zongyuan Ge, David Reutens, Terence O’Brien, Wendyl D’Souza, Piero Perucca, Sandra Reeder, Armin Nikpour, Chong Wong, Michelle Kiley, Jacqui-Lyn Saw, John-Paul Nicolo, Udaya Seneviratne, Patrick Carney, Dean Jones, Ernest Somerville, Clare Stapleton, Emma Foster, Lata Vadlamudi, David N Vaughan, James Lee, Tania Farrar, Mark Howard, Robert Sparrow, Zhibin Chen, Patrick Kwan

BMJ Open Apr 2025, 15 (4) e086607; DOI: 10.1136/bmjopen-2024-086607
Longitudinal dynamics of pulse wave velocity in the days after acute ischaemic stroke: prospective cohort study
Kurt Moelgg, Anel Karisik, Benjamin Dejakum, Silvia Felicetti, Christian Boehme, Lukas Mayer-Suess, Thomas Toell, Michael Knoflach, Stefan Kiechl, Raimund Pechlaner

BMJ Open Apr 2025, 15 (4) e089304; DOI: 10.1136/bmjopen-2024-089304

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