Table 3

Events schedule

Events schedule
Procedure	Screening	T0	First study period	T1	Second study period	T2	T3
Week	0	0	0–6	6	12-Jun	12	18
Eligibility assessment
Informed consent	X
Inclusion/exclusion criteria	X
Study assessments
Aerobic fitness
CPET	X	X^*	X	X	X	X	X
Steep ramp test		X		X
Sarcopenia
Muscle thickness		X		X		X	X
SARC-F questionnaire		X		X		X	X
Liver disease specific frailty
Liver Frailty Index		X		X		X	X
Anthropometry
BMI		X		X		X	X
Quality of life
SF-36		X		X		X	X
LDSI		X		X		X	X
Perceived fatigue
MFI		X		X		X	X
Anxiety and depression
STAI-6		X		X X		X X	X X
PHQ-9		X
Hepatic encephalopathy
West Haven		X		X		X	X
ANT		X		X		X	X
Microbiome composition
Stool sample		X		X		X	X

*Results of the screening CPET are used for the T0 assessment.
ANT, animal naming test; BMI, body mass index; CPET, cardiopulmonary exercise test; LDSI, liver disease symptom index; MFI, multidimensional fatigue index; PHQ-9, 9-item Patient Health Questionnaire; SARC-F, Strength, Assistance with walking, Rising from a chair, Climbing stairs and Falls; SF-36, 36 item short form; STAI-6, 6 item Spielberger State-Trait Anxiety Inventory.