Table 1

Intervention-outcome domains for the evidence gap map

Intervention domainsIndicatorsDescription

  • Medicinal plants

  • Kind/type of plant (shrub, herb, tree)

  • The type of plant, including geographical location

  • Parts of the plant used (leaves, back, roots, shoots)

  • Plant material used, either entire plant or its parts (single or combined)

  • Name of the plant species

  • Include both genus and species names

  • Age of the plant/part

  • Either young or mature/old plant/or parts

  • Plant extract

  • Water extract

  • Extraction time, extraction temperature, granulometry of the plant, proportion of plant and solvent used

  • Methanol extract

  • Extraction time, extraction temperature, granulometry of the plant, proportion of plant and solvent used

  • Ether extract

  • Extraction time, extraction temperature, granulometry of the plant, proportion of plant and solvent used

  • Chloroform extract

  • Extraction time, extraction temperature, granulometry of the plant, proportion of plant and solvent used

  • Ethanolic extract

  • Extraction time, extraction temperature, granulometry of the plant, proportion of plant and solvent used

  • Crude extract

  • Proportions of the different extracts in the mixture

Outcomes domainsIndicatorsDescription

  • Clinical outcomes

  • Fever

  • Relief from fever

  • Body aches/malaise

  • Relief from body aches

  • Joint pains

  • Relief from joint pains

  • Nausea/vomiting

  • Relief from vomiting

  • Appetite

  • Gaining of appetite

  • Adequate clinical and parasitological response32

  • Resolution of clinical symptoms of malaria and plasmodium parasite clearance

  • Laboratory outcomes

  • IC50,

  • Inhibitory concentration killing 50% of parasites

  • RSA0–3 hours

  • Concentration killing early-stage parasites (0–3 hours)

  • TSA50

  • Concentration killing 50% of trophozoites

  • IC50: Inhibitory Concentration; RSA0-3hours: RingStageSurvivalAssay;TSA50:TrophozzoiteSurvivalAssay