Table 1

Characteristics of studies for manual therapy for infantile colic

Authors	Participants/n/age/gender	Timing of intervention	Number of studies: type of studies included in review	Method of data synthesis (narrative/meta-analysis)
Alcantara et al38	Infants/n=980 (where reported)/<18 years/gender not reported	<4 weeks/30 days	26: 3 clinical trials, 2 survey studies, 6 case reports, 2 case series, 4 cohort studies, 5 commentaries and 4 reviews of the literature	Narrative
Carnes etal43	Infants/n=866 (one study not reported)/gender not reported	8 days to 4 weeks FU 2–11 years	11: 5× RCTs, 1× retrospective review, 2× cohort studies, 3× cases series	Both
Clar etal39	Infants/n=not reported	Not reported	19: 10 SRs and 9 RCTs	Narrative
Dobson etal16	Infants/n=358/birth–12 weeks/gender percentages varied (where reported) between 34% and 93% male (mean 56%, median 47%)	8 days to 6 weeks	6 RCTs	Meta-analysis
Driehuis etal42	Infants/n=283/birth–10 weeks/gender not reported	8–14 days	4 RCTs	Both
Ernst41	Infants/n=198/2–10 weeks/gender not specified	8–15 days	3 RCTs	Narrative
Gleberzon etal36	Infants/n=1459/birth–3 years	Immediate—4 weeks	6: 3× RCTs, 1× prospective uncontrolled, 2× retrospective studies	Narrative
Parnell Prevost etal40	Infants/n=>4000/0–12 weeks	Not reported	5: 4 RCTs, 1 obs	Narrative
Posadzki and Ernst27	Infants/n=not reported	Not reported	2 SRs	Narrative
Posadzki et al37	Infants/n=28/1–12 weeks	28 days	1 RCT	Narrative
Salehi etal28	Infants/n=368/age=not reported	Not reported	11 SRs—2 SRs for colic	Narrative