Variables and schedule of data collection
| No. | Variable | Data source | Schedule | ||
| Medical notes | Measured/collected at clinic | Baseline | Follow-up | ||
| 1 | Age | ✓ | ✓ | ||
| 2 | Sex | ✓ | ✓ | ||
| 3 | Ethnicity | ✓ | ✓ | ||
| 4 | Marital status | ✓ | ✓ | ||
| 5 | Education | ✓ | ✓ | ||
| 6 | Duration of hypertension | ✓ | ✓ | ||
| 7 | Past medical history | ✓ | ✓ | ||
| 8 | Alcohol consumption | ✓ | ✓ | ✓ | |
| 9 | Smoking | ✓ | ✓ | ✓ | |
| 10 | Height | ✓ | ✓ | ✓ | |
| 11 | Weight | ✓ | ✓ | ✓ | |
| 12 | Clinic blood pressure (sitting and standing) | ✓ | ✓ | ✓ | |
| 13 | Cholesterol (total and HDL) | ✓ | ✓ | ||
| 14 | Estimated glomerular filtration rate | ✓ | ✓ | ||
| 15 | Prescribed or over-the-counter medications (all medications)* | ✓ | ✓ | ✓ | ✓ |
| 16 | Quality of life (according to EQ-5D-5L)26 | ✓ | ✓ | ✓ | |
| 17 | Functional independence (defined by modified Rankin Scale)38 | ✓ | ✓ | ||
| 18 | Frailty (according to the FRAIL scale)39 | ✓ | ✓ | ✓ | |
| 19 | Frailty (according to the frailty index and electronic frailty index)22 40 | ✓ | ✓ | ✓ | ✓ |
| 20 | Cognitive function (defined by the Montreal Cognitive Assessment)41 | ✓ | ✓ | ||
| 21 | Adherence to medication (according to the Medication Adherence Rating Scale Questionnaire)42 | ✓ | ✓ | ✓ | |
| 22 | Adherence to medication reduction | ✓ | ✓ | ||
| 23 | ICD-10 coded cardiovascular events and mortality during the trial | ✓ | ✓ | ||
| 24 | Recording of potential side effects to medication | ✓ | ✓ | ✓ | |
| 25 | Recording of adverse events | ✓ | ✓ | ✓ | |
*Drug substance/name, formulation, dose, frequency, start date and adherence over past 12 months (according to clinical system).
HDL, high-density lipoprotein; ICD, International Statistical Classification of Diseases and Related Health Problems.