RT Journal Article SR Electronic T1 Is neighbourhood income inequality associated with maternal mental health? A longitudinal analysis of pregnant and new mothers living in Calgary, Alberta JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e049220 DO 10.1136/bmjopen-2021-049220 VO 11 IS 12 A1 Lowe, Samuel AJ A1 McDonald, Sheila A1 Senthilselvan, Ambikaipakan A1 Nykiforuk, Candace IJ A1 Chari, Radha A1 Pabayo, Roman YR 2021 UL http://bmjopen.bmj.com/content/11/12/e049220.abstract AB Objectives Rising income inequality is a potential risk factor for poor mental health, however, little work has investigated this link among mothers. Our goal was to determine if neighbourhood-level income inequality was associated with maternal mental health over time.Design Secondary data analysis using a retrospective cohort study design.Setting and participants Data from the All Our Families (AOF) ongoing cohort study in the city of Calgary (Canada) were used, with our sample including 2461 mothers. Participant data were collected at six time points from 2008 to 2014, corresponding to <25 weeks of pregnancy to 3 years post partum. AOF mothers were linked to 196 geographically defined Calgary neighbourhoods using postal code information and 2006 Canada Census data.Main outcome measures Anxiety symptoms measured using the Spielberger State Anxiety Inventory, and depressive symptoms measured using the Edinburgh Postnatal Depression Scale and the Centre for Epidemiologic Studies-Depression Scale.Results Multilevel regression modelling was used to quantify the associations between neighbourhood-level income inequality and continuous mental health symptoms over time. For anxiety symptoms, the interaction term between neighbourhood Gini and time was significant (β=0.0017, 95% CI=0.00049 to 0.0028, p=0.005), indicating an excess rate of change over time. Specifically, a SD increase in Gini (Z-score) was associated with an average monthly rate increase in anxiety symptom scores of 1.001% per month. While depressive symptom scores followed similar longitudinal trajectories across levels of income inequality, we did not find significant evidence for an association between inequality and depressive symptoms. There was no evidence of a cross-level interaction between inequality and household income on either outcome.Conclusion Income inequality within neighbourhoods appears to adversely impact the mental health trajectories of pregnant and new mothers. Further research is needed to understand the mechanisms that explain this relationship, and how interventions to reduce income inequality could benefit mental health.Data may be obtained from a third party and are not publicly available. Data from the AOF cohort are available through a data access request directly through the All Our Families Study (https://allourfamiliesstudy.com/data-access/) or through Secondary Analysis to Generate Evidence (PolicyWise for Children and Families; https://redcap.ualberta.ca/surveys/?s=HALHFCRTHL)