RT Journal Article
SR Electronic
T1 Safety and efficacy of tranexamic acid in bleeding paediatric trauma patients: a systematic review protocol
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e012947
DO 10.1136/bmjopen-2016-012947
VO 6
IS 9
A1 Urban, Denisa
A1 Dehaeck, Ruben
A1 Lorenzetti, Diane
A1 Guilfoyle, Jonathan
A1 Poon, Man-Chiu
A1 Steele, MacGregor
A1 Lardner, David
A1 Ma, Irene Wai Yan
A1 Brindle, Mary Elizabeth
YR 2016
UL http://bmjopen.bmj.com/content/6/9/e012947.abstract
AB Introduction Trauma is the leading cause of death among children aged 1–18. Studies indicate that better control of bleeding could potentially prevent 10–20% of trauma-related deaths. The antifibrinolytic agent tranexamic acid (TxA) has shown promise in haemorrhage control in adult trauma patients. However, information on the potential benefits of TxA in children remains sparse. This review proposes to evaluate the current uses, benefits and adverse effects of TxA in the bleeding paediatric trauma population.Methods and analysis A structured search of bibliographic databases (eg, MEDLINE, EMBASE, PubMed, CINAHL, Cochrane CENTRAL) has been undertaken to retrieve randomised controlled trials and cohort studies that describe the use of TxA in paediatric trauma patients. To ensure that all relevant data were captured, the search did not contain any restrictions on language or publication time. After deduplication, citations will be screened independently by 2 authors, and selected for inclusion based on prespecified criteria. Data extraction and risk of bias assessment will be performed independently and in duplicate. Meta-analytic methods will be employed wherever appropriate.Ethics and dissemination This study will not involve primary data collection, and formal ethical approval will therefore not be required. The findings of this study will be disseminated through a peer-reviewed publication and at relevant conference meetings.Trial registration number CRD42016038023.